Irisin restrains neuroinflammation in mouse experimental autoimmune encephalomyelitis via regulating microglia activation
In conclusion, these results collectively suggest that Irisin alleviates EAE progression by suppressing microglia activation via the NF-κBp65 pathway, highlighting its potential as a promising therapeutic target for multiple sclerosis treatment.
Authors
- Qiuxia Zhang (ORCID: https://orcid.org/0000-0001-7900-5549)
- Li Yang (ORCID: https://orcid.org/0000-0003-2716-3793)
- Linjie Zhang (ORCID: https://orcid.org/0000-0002-6100-4115)
- Ning Zhao (ORCID: https://orcid.org/0000-0002-2866-5149)
Institutions
- Tianjin Medical University General Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.3389/fphar.2025.1561939
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- National Natural Science Foundation of China
- Tianjin Municipal Education Commission