Synergistic amelioration of renal oxidative stress, inflammation, and fibrosis by combination of metformin and Clinacanthus nutans leave extracts in a type 2 diabetic rat model
Our findings provide a scientific basis for the clinical application of CN and suggest a new strategy for preventing nephrotoxicity and other kidney diseases in diabetic patients.
Authors
- Pongrapee Laorodphun (ORCID: https://orcid.org/0000-0002-1344-9777)
- Sureeporn Suriyaprom (ORCID: https://orcid.org/0009-0006-6827-9564)
- Yingmanee Tragoolpua (ORCID: https://orcid.org/0000-0002-0754-0638)
- Thida Kaewkod (ORCID: https://orcid.org/0000-0003-1779-7629)
- Phatchawan Arjinajarn
- Saruda Thongyim
- Aussara Panya (ORCID: https://orcid.org/0000-0002-3634-1881)
- Pornchita Maphet
Institutions
- Chiang Mai University (TH)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.3389/fphar.2025.1558341
- Citations
- 1
- Primary Topic
- Medicinal Plant Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.38