Screening and transcriptomic analysis of anti-Sporothrix globosa targeting AbaA
Two small-molecule drugs exhibit the ability to inhibit <i>Sporothrix</i> and treat sporotrichosis both in vitro and in murine models, suggesting their potential for development as therapeutic agents for sporotrichosis. And qRT-PCR and transcriptome results underscore the significance of the <i>aba</i>A gene in <i>Sporothrix</i>. Our results lay the foundation for the search for new treatments for other mycosis.
Authors
- Ying Wang (ORCID: https://orcid.org/0000-0001-6642-543X)
- Fangliang Zheng (ORCID: https://orcid.org/0000-0002-3299-4543)
- Xiaoguang Fan (ORCID: https://orcid.org/0000-0002-8649-7833)
- Zhenying Zhang (ORCID: https://orcid.org/0000-0002-4443-0649)
- C.-C. Han
- Xiaoyan Wu (ORCID: https://orcid.org/0009-0007-7890-8341)
Institutions
- Sun Yat-sen University (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- Shenyang Academy of Environmental Sciences (China) (CN)
- Eighth Affiliated Hospital of Sun Yat-sen University
- University of Hong Kong (HK)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.3389/fmicb.2025.1546020
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00