Dl-3-n-butylphthalide attenuates DOX-induced cardiotoxicity in mice by inhibiting Nrf2/Keap1 complex formation
This study indicate that NBP alleviates DOX-induced cardiotoxicity by inhibiting Nrf2/Keap1 complex formation, highlighting its potential as a therapeutic agent for DICT and suggest that Nrf2/Keap1 may be a potential therapeutic target for the management of this condition.
Authors
- Cong Zhao (ORCID: https://orcid.org/0000-0003-3647-7567)
- Yixiao Yan
- Marong Fang (ORCID: https://orcid.org/0000-0002-6636-4347)
- Gaozhi Chen (ORCID: https://orcid.org/0009-0005-7604-8128)
- Yuge Ran
- Tong Chen (ORCID: https://orcid.org/0000-0001-8470-8900)
- Xuelian Wang (ORCID: https://orcid.org/0000-0003-0671-5958)
- Xiang Cheng (ORCID: https://orcid.org/0000-0002-3308-3506)
- Xinru Lin
- Lili Fu (ORCID: https://orcid.org/0009-0009-0062-7931)
- Shaokang Li
Institutions
- Wenzhou Medical University (CN)
- Zhejiang Lab (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.3389/fphar.2025.1542296
- Citations
- 2
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.68