Proton pump inhibitors use and risk of type 2 diabetes mellitus: correlation analysis, prediction model construction, and key genes identification

Our findings revealed that PPI treatment can increase the risk of T2DM. Additionally, we were successful in constructing a new nomogram to identify individuals at high risk of developing T2DM among patients using PPIs and completed a preliminary exploration of possible gene targets and mechanisms. Our study will be useful in alerting clinicians to the T2DM risk involved in PPI treatment and allowing them to take early prevention and intervention measures.