Potential common mechanisms between primary Sjögren’s syndrome and Hashimoto’s thyroiditis: a public databases-based study
We analysed databases and gene expression data for pSS and HT. We identified two genes (STAT1, PTPRC) as potential biomarkers of disease activity in pSS and HT. We also gained new insights into the cellular and molecular mechanisms associated with pSS and HT. Based on the key genes and cross-talk genes, we predicted potential drugs and protein domains for pSS and HT.
Authors
- Rosi Wang
- Dong Wu (ORCID: https://orcid.org/0000-0002-9469-831X)
- Shaowen Tang (ORCID: https://orcid.org/0000-0001-5879-8594)
- Jiang Chen (ORCID: https://orcid.org/0000-0001-6879-6525)
- Zonghe Xu
- Yanjun Lin (ORCID: https://orcid.org/0000-0003-0526-8818)
- WI Wei (ORCID: https://orcid.org/0000-0002-6281-7126)
- Yan Li (ORCID: https://orcid.org/0000-0002-0366-2048)
- Yan Lin (ORCID: https://orcid.org/0009-0005-9357-4832)
- Yan Xing (ORCID: https://orcid.org/0000-0003-2150-1448)
- Qiu Fang
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-04-29
- DOI
- https://doi.org/10.3389/fgene.2025.1520332
- Citations
- 1
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 1.16