Skin Anti-Aging Effect of a Melatonin-based in & Out Strategy in Comparison with Topical Treatment Alone: A Randomized, Assessor-Blinded, Prospective Trial with VISIA evaluation

Aim: Topical use of Mel has demonstrated beneficial effects in skin aging treatment. So far, no clinical data are available regarding the anti skin aging effect of an “In & Out” regimen consisting of a Mel-based cream and a Mel-based (0.5 mg) dietary supplementation containing also hyaluronic acid and apigenin. Methods: In a 12-week multicenter, randomized, assessor-blind trial, fifty subjects, with mild to moderate face skin aging were randomized to cream treatment (Group A; n=25) or to cream treatment plus a Mel-based oral supplementation (Group B; n=25). The main outcome was the evolution of the Skin Ageing Global Score (SAGS) evaluated at baseline, week 6, and week 12. VISIA analysis was performed in a subgroup of 20 subjects. Results: At baseline, the SAGS score was 13±3 and 14±4 in Group A and Group B, respectively. In both groups, the SAGS significantly decreased after 6 (-10%) and 12 weeks (-23% and -27% for Group A and B, respectively), confirming the efficacy of the topical treatment and suggesting a greater clinical improvement for the combination treatments compared to the topical treatment alone. These results were supported by the VISIA analysis.