Urinary amino acid metabolomic profiling and its association with childhood obesity in prepubescent individuals
Our findings indicate that obese and overweight children exhibit a particular urinary amino acid fingerprint which is similar to that reported in studies with plasma. The altered amino acids, particularly tyrosine, are frequently associated with impairments in glucose homeostasis, insulin resistance, and diabetes mellitus type 2. Potential mechanisms for increasing the levels of these amino acids in excess of weight may include enhanced protein degradation and impaired oxidative metabolism.
Authors
- María del Carmen Bisi Molina (ORCID: https://orcid.org/0000-0001-8746-5860)
- Marcelo Yudi Icimoto (ORCID: https://orcid.org/0000-0002-0746-5279)
- Dulce Elena Casarini (ORCID: https://orcid.org/0000-0003-1912-4292)
- Fernando Barbosa (ORCID: https://orcid.org/0000-0002-2498-0619)
- Mariana Zuccherato Bocato (ORCID: https://orcid.org/0000-0002-5129-3320)
- Lilian Caroline Gonçalves de Oliveira (ORCID: https://orcid.org/0000-0001-5117-6979)
- Nayara Azinheira Nobrega Cruz (ORCID: https://orcid.org/0000-0002-9689-9545)
- Mariana Doce Passadore (ORCID: https://orcid.org/0000-0003-3084-4020)
- Leonardo A. Ferreira (ORCID: https://orcid.org/0000-0001-5303-2776)
- José Geraldo Mill
Institutions
- Universidade de São Paulo (BR)
- Universidade Presbiteriana Mackenzie (BR)
- Universidade Federal do Espírito Santo (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.3389/fphys.2025.1524939
- Citations
- 2
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.61