Resistin upregulates fatty acid oxidation in synoviocytes of metabolic syndrome-associated knee osteoarthritis via CAP1/PKA/CREB to promote inflammation and catabolism
This study clarifies the mechanism by which MetS causes synovitis from a metabolic perspective and provides new ideas for further research and treatment of MetS-KOA.
Authors
- Jun-Wei Tian
- Yi Leng
- Xin Qi (ORCID: https://orcid.org/0000-0002-8912-8523)
- Ziran Bai
- Lu Ding (ORCID: https://orcid.org/0000-0001-7547-2844)
- Minli Jin
- Jianzeng Zhang (ORCID: https://orcid.org/0000-0002-0151-2484)
- Guan Wang (ORCID: https://orcid.org/0000-0001-5719-5417)
- Wei Jing (ORCID: https://orcid.org/0000-0003-3318-1090)
- Xia Li (ORCID: https://orcid.org/0000-0002-3246-4462)
- Yifan Huang (ORCID: https://orcid.org/0000-0002-0325-4706)
- Jinyi Ren
Institutions
- Dalian Medical University (CN)
- Jilin University (CN)
- First Hospital of Jilin University (CN)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1186/s13075-025-03527-6
- Citations
- 5
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 8.34
Funders
- National Natural Science Foundation of China
- Jilin University
- First Hospital of Jilin University