Orbital mesenchymal chondrosarcoma and its specific fusion gene HEY1-NCOA2
We summarized the clinical features, treatments, and prognosis of orbital MC, including our cases and the literature. The expression of COL2A1 and Bcl2 is elevated in HEY1-NCOA2-positive tissues, and they promote tumor cell growth by regulating cell proliferation, apoptosis, epithelial-mesenchymal transition, and drug resistance. For HEY1-NCOA2-positive patients, given the high expression of CD99, drugs targeting the MAPK pathway may be an effective treatment.
Authors
- Jiaqi Lin (ORCID: https://orcid.org/0000-0003-3195-6569)
- Yang Liu (ORCID: https://orcid.org/0000-0002-0367-8189)
- Qing Wang (ORCID: https://orcid.org/0000-0003-1679-0169)
- Li Zhu (ORCID: https://orcid.org/0000-0001-5249-6536)
- Ting-Ting Lin
- Jinbo Zhao (ORCID: https://orcid.org/0000-0002-7806-6072)
Institutions
- Tianjin Medical University Eye Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- BMC Ophthalmology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1186/s12886-025-04082-z
- Citations
- 2
- Primary Topic
- Bone Tumor Diagnosis and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.34