NRN1 may Modulate Tau Phosphorylation and Neuronal Apoptosis in AD via the PIGU-CASP3 Axis
NRN1 may mitigate tau protein phosphorylation and neuronal apoptosis by modulating the PIGU-CASP3 pathway in AD. This finding offers novel insights into NRN1 as a potential target for the treatment of AD.
Authors
- Min Li (ORCID: https://orcid.org/0000-0002-5619-8955)
- Yuhang Gao (ORCID: https://orcid.org/0000-0002-2942-8102)
- Zhenyu Wang (ORCID: https://orcid.org/0009-0002-6679-9612)
- J. Wang (ORCID: https://orcid.org/0000-0003-2483-3675)
- Hongdan Fu
- Cunzhong Yuan (ORCID: https://orcid.org/0000-0002-8785-2139)
- Jiawei Sun (ORCID: https://orcid.org/0000-0002-9527-0219)
- Yuepeng Zhang (ORCID: https://orcid.org/0000-0002-6520-2880)
- Wen Cheng (ORCID: https://orcid.org/0000-0003-0689-1695)
- Jia Zhang (ORCID: https://orcid.org/0000-0001-8982-6666)
- Changyu Chen (ORCID: https://orcid.org/0000-0003-1235-6787)
- Hui Zhu (ORCID: https://orcid.org/0000-0003-0852-6894)
- Jinmei Zhu (ORCID: https://orcid.org/0000-0003-3667-6347)
Institutions
- Shihezi University (CN)
- Sun Yat-sen University (CN)
- Peking University (CN)
- First Affiliated Hospital of Shihezi University Medical College (CN)
Publication Details
- Journal
- Current Alzheimer Research
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2174/0115672050361366250328040542
- Primary Topic
- 14-3-3 protein interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00