Impact of diabetes and metformin on cuproptosis and ferroptosis in breast cancer patients: an immunohistochemical analysis
Metformin may simultaneously enhance both cuproptosis and ferroptosis in breast cancer. FDX1 expression could serve as a prognostic marker for survival, especially in diabetic patients, providing insights into targeting metabolic and cell death pathways in breast cancer therapy.
Authors
- Tao Chen (ORCID: https://orcid.org/0000-0002-5147-9918)
- Hongxia Cui (ORCID: https://orcid.org/0000-0002-0137-2450)
- Jing Du (ORCID: https://orcid.org/0000-0001-7519-8531)
- Changwen Li
- Na Deng (ORCID: https://orcid.org/0000-0002-4557-5372)
- Cheng Ma (ORCID: https://orcid.org/0000-0002-9767-8066)
- Yuanyuan Li
- Xiaoxin Li (ORCID: https://orcid.org/0000-0001-8271-299X)
- Chuangang Tang (ORCID: https://orcid.org/0000-0003-2447-5097)
- Chunyan Zhou
Institutions
- Jiangsu Normal University (CN)
- Xuzhou Medical College (CN)
- Affiliated Hospital of Xuzhou Medical College (CN)
- Xuzhou Central Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1007/s12672-025-02425-2
- Citations
- 1
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Government of Jiangsu Province
- Wu Jieping Medical Foundation