Efficient AAV8 delivery to the liver via isolated hepatic perfusion and analysis of hepatic lobule transduction patterns
In this study, we found that IHP is an effective strategy for AAV8 delivery. In addition, the distribution characteristics of AAV8, when delivered in cynomolgus monkey via IHP, provide candidate vector delivery schemes for gene therapy for different types of genetic liver diseases.
Authors
- Xiaolu Guo (ORCID: https://orcid.org/0000-0002-0443-7627)
- Qiong Ke (ORCID: https://orcid.org/0000-0003-2566-7242)
- Rui Fang (ORCID: https://orcid.org/0000-0003-0020-8488)
- Xueying Huang (ORCID: https://orcid.org/0000-0001-8316-9036)
- C. Wang (ORCID: https://orcid.org/0000-0003-2775-8252)
- Li Wang (ORCID: https://orcid.org/0000-0003-0571-4603)
- Xiaomei Liu (ORCID: https://orcid.org/0000-0001-6134-0197)
- Jianqi Feng
- Jianrong Liu (ORCID: https://orcid.org/0000-0001-8163-7529)
- Zhipeng Tan (ORCID: https://orcid.org/0000-0001-6661-242X)
- Zhuoran Li (ORCID: https://orcid.org/0000-0002-2715-7716)
- Ye Zhang (ORCID: https://orcid.org/0009-0003-8906-1300)
- Mingming Fan
Institutions
- Sun Yat-sen University (CN)
- Guangzhou Development Zone Hospital (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Liver Research
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1016/j.livres.2025.04.006
- Citations
- 1
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.82