Phase-dependent closed-loop deep brain stimulation of the fornix provides bidirectional manipulation of hippocampal theta oscillations
Our findings demonstrate that closed-loop fx-DBS is a viable method of modulating the amplitude of hippocampal theta oscillations that could be applied in human devices to provide a constructive intervention with the potential to boost memory circuit function in AD.
Authors
- Brook A. L. Perry (ORCID: https://orcid.org/0000-0001-8598-1458)
- Colin G. McNamara (ORCID: https://orcid.org/0000-0001-8266-9266)
- Andrew Sharott (ORCID: https://orcid.org/0000-0002-1594-3349)
- Melissa M. Jones (ORCID: https://orcid.org/0000-0002-5319-4430)
- Oliver Härmson (ORCID: https://orcid.org/0000-0003-0556-1539)
- Isaac Grennan
- Anna Verghese
Institutions
- University College Cork (IE)
- University of Oxford (GB)
- MRC Brain Network Dynamics Unit (GB)
- Medical Research Council (GB)
Publication Details
- Journal
- Brain stimulation
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1016/j.brs.2025.04.019
- Citations
- 6
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.34