Effect of ABCB1 SNP polymorphisms on the plasma concentrations and clinical outcomes of rivaroxaban in Chinese NVAF patients: a population pharmacokinetic-based study
The PPK model incorporated CL/F and V/F with the covariate AST/ALT. Model-based simulations revealed that ABCB1 1236C>T, ABCB1 c.2482-2236C>T, and ABCB1 3435C>T genotypes had significant impacts on the plasma concentrations of rivaroxaban. Specifically, ABCB1 c.2482-2236C>T and ABCB1 3435C>T genotypes were associated with bleeding events and thromboembolic events, respectively.
Authors
- Youqi Huang
- Xingang Li (ORCID: https://orcid.org/0000-0001-6726-9571)
- Libin Zhao (ORCID: https://orcid.org/0009-0003-9271-4691)
- Ze Li (ORCID: https://orcid.org/0000-0002-2818-4396)
- Qin Liu (ORCID: https://orcid.org/0000-0001-9964-580X)
- Fei Wang (ORCID: https://orcid.org/0000-0003-1038-3730)
- Honghong Wang (ORCID: https://orcid.org/0000-0002-3484-8929)
- Yuze Lin
- Mingyu Chen (ORCID: https://orcid.org/0000-0002-6910-5877)
- Hongjin Gao
Institutions
- Fujian Medical University (CN)
- Capital Medical University (CN)
- Liuzhou Maternal and Child Health Hospital (CN)
- Fujian Provincial Hospital (CN)
- Beijing Friendship Hospital (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.3389/fphar.2025.1574949
- Citations
- 1
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.39