Pathological and clinical insights into DICER1 hotspot mutated Sertoli-Leydig cell tumors: a comparative analysis
This study demonstrates that DICER1-mutant and wildtype SLCTs have marked differences in pathological morphology and clinical manifestation. DICER1-mutatant SLCTs display worse prognosis, higher proliferative activity, and potentially more active immune microenvironments, which underscores the importance of genetic testing in diagnosing and assessing the prognosis of SLCTs.
Authors
- Xianlong Chen (ORCID: https://orcid.org/0000-0002-3677-4281)
- Shuangni Yu (ORCID: https://orcid.org/0000-0002-3745-1097)
- Jingci Chen (ORCID: https://orcid.org/0000-0002-2349-3309)
- Shengwei Mo (ORCID: https://orcid.org/0000-0001-9401-3141)
- Zhaohui Lu
- Zhuozhen Lyu
- Jie Chen (ORCID: https://orcid.org/0000-0001-8113-3515)
- Yilin Liu (ORCID: https://orcid.org/0000-0002-2540-1295)
- Heng Ma (ORCID: https://orcid.org/0000-0003-1091-2591)
- Xiaoyan Chang (ORCID: https://orcid.org/0000-0003-0963-642X)
- Pengyan Wang (ORCID: https://orcid.org/0000-0002-8967-986X)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Diagnostic Pathology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1186/s13000-025-01657-8
- Citations
- 3
- Primary Topic
- Testicular diseases and treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- Peking Union Medical College Hospital
- Peking Union Medical College