Sheep challenged with sheep-derived type II Mycobacterium avium subsp. paratuberculosis: the first experimental model of paratuberculosis in China
To the best of our knowledge, this is the first experimental MAP challenge study on sheep in China. Polymerase chain reaction detection was more sensitive than MAP culture, whereas enzyme-linked immunosorbent assay was less sensitive for detecting MAP-specific antibodies. IFN-γ and IL-10 responses may serve as targets for monitoring PTB progression. The severity of ileal lesions and acid-fast bacilli grading play crucial roles in the understanding of infection dynamics. Currently, early PTB diagnosis requires a combination of multiple sample types and detection methods.
Authors
- Wenjun Meng (ORCID: https://orcid.org/0000-0002-4244-8044)
- Chenguang Du (ORCID: https://orcid.org/0000-0002-3548-7512)
- W. F. Mader (ORCID: https://orcid.org/0000-0002-7344-998X)
- Rui Chen (ORCID: https://orcid.org/0000-0002-3589-9103)
- Mengyuan Li (ORCID: https://orcid.org/0000-0003-3071-5579)
- Yonghong Liu (ORCID: https://orcid.org/0000-0003-4432-9433)
- Rong Zhang (ORCID: https://orcid.org/0000-0002-2174-7985)
- Weihong Zhao (ORCID: https://orcid.org/0009-0000-8422-9723)
- Yulin Ding (ORCID: https://orcid.org/0000-0002-3082-3759)
- Bo Yang (ORCID: https://orcid.org/0000-0002-8918-586X)
- Li Zhao (ORCID: https://orcid.org/0000-0001-8538-5605)
- Siqin Tunala
- Hasi Bayaer
- Alateng Bagen
Institutions
- Inner Mongolia Agricultural University (CN)
- China Animal Disease Control Center (CN)
- Ministry of Agriculture (ID)
- Ministry of Agriculture and Rural Affairs (CN)
Publication Details
- Journal
- BMC Veterinary Research
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1186/s12917-025-04765-1
- Citations
- 1
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Natural Science Foundation of Inner Mongolia