Endothelial KLF15/VASN Axis Inhibits Angiogenesis via Activation of Notch1 Signaling
The KLF15/VASN axis negatively regulates angiogenesis by activating Notch1 signaling. KLF15 and VASN might represent novel therapeutic targets for the treatment of impaired angiogenesis-related diseases and tumors.
Authors
- Ji‐Guang Wang (ORCID: https://orcid.org/0000-0001-8511-1524)
- Han‐Dan Zhou
- Xiaodong Li (ORCID: https://orcid.org/0000-0002-3771-6286)
- Jing Chen (ORCID: https://orcid.org/0000-0002-2324-6607)
- Jiajia Zhao (ORCID: https://orcid.org/0000-0002-3700-0042)
- Mona Hong
- Pingjin Gao (ORCID: https://orcid.org/0000-0002-7750-3314)
- Jia Zhang
Institutions
- Harbin Medical University (CN)
- Shanghai Institute of Hypertension (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1161/circresaha.124.325494
- Citations
- 4
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 3.22