Causal Relevance of Lp(a) for Coronary Heart Disease and Stroke Types in East Asian and European Ancestry Populations: A Mendelian Randomization Study
The effects of Lp(a) on risk of myocardial infarction and large-artery IS were comparable in East Asian and European individuals, suggesting that people with either ancestry could expect comparable proportional benefits for equivalent reductions in Lp(a), but there was little effect on other stroke types.
Authors
- Michael Hill (ORCID: https://orcid.org/0000-0002-3861-6105)
- Daniel Avery (ORCID: https://orcid.org/0000-0002-9823-9575)
- Paul Sherliker (ORCID: https://orcid.org/0009-0003-9559-6029)
- Ling Yang (ORCID: https://orcid.org/0000-0001-5750-6588)
- Dianjianyi Sun (ORCID: https://orcid.org/0000-0003-3651-6693)
- Canqing Yu (ORCID: https://orcid.org/0000-0002-0019-0014)
- Kuang Lin (ORCID: https://orcid.org/0000-0002-7360-3385)
- Robert Clarke (ORCID: https://orcid.org/0000-0002-9802-8241)
- Christiana Kartsonaki (ORCID: https://orcid.org/0000-0002-3981-3418)
- Iona Y. Millwood (ORCID: https://orcid.org/0000-0002-0807-0682)
- Robin G. Walters (ORCID: https://orcid.org/0000-0002-9179-0321)
- Derrick Bennett (ORCID: https://orcid.org/0000-0002-9170-8447)
- Santica M. Marcovina (ORCID: https://orcid.org/0000-0002-9118-8488)
- Jun Lv (ORCID: https://orcid.org/0000-0001-7916-3870)
- Neil Wright (ORCID: https://orcid.org/0000-0002-3946-1870)
- Sarah Parish (ORCID: https://orcid.org/0000-0003-3532-0832)
- Huaidong Du (ORCID: https://orcid.org/0000-0002-9814-0049)
- Rory Collins (ORCID: https://orcid.org/0000-0001-8288-8602)
- Yiping Chen (ORCID: https://orcid.org/0000-0002-4973-0296)
- Liming Li (ORCID: https://orcid.org/0000-0001-5873-7089)
- Zhengming Chen (ORCID: https://orcid.org/0000-0001-6423-105X)
- Chan Qu
- Xiaoming Yang (ORCID: https://orcid.org/0000-0002-6570-0273)
Institutions
- Medpace (United States) (US)
- Peking University (CN)
- Ministry of Education (RO)
- Office of Readiness and Response (US)
- Nuffield Health (GB)
- Liu Zhou Center for Disease Prevention and Control (CN)
Publication Details
- Journal
- Circulation
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1161/circulationaha.124.072086
- Citations
- 13
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 26.08