USP2-induced upregulation of LEF1 through deubiquitination relieves osteoporosis development by promoting the osteogenic differentiation of bone marrow mesenchymal stem cells
Our findings provide the first demonstration of the USP2/LEF1 cascade that enhances the osteogenic differentiation of hBMSCs, broadening the field for the development of BMSCs as effective agents in osteoporosis therapy.
Authors
- Hanwen Xing
- Yue Zhang (ORCID: https://orcid.org/0000-0003-3568-0395)
- Jie Cao (ORCID: https://orcid.org/0000-0001-9803-3836)
- Zhihong Zhang (ORCID: https://orcid.org/0000-0003-4458-1065)
- Chun‐Feng Liu (ORCID: https://orcid.org/0000-0002-8364-0219)
- Linshuo Li
Institutions
- Kailuan General Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1186/s13018-025-05834-9
- Citations
- 3
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 2.42