PYGO2 regulates IL10 and plays immunosuppressive role through ESCC progression
PYGO2 may regulate IL10 through Wnt/β-catenin signaling pathway, suggesting a possible oncogenic role for PYGO2/IL10 axis in ESCC tumorigenesis. Considering the involvement of IL10 as an anti-inflammatory cytokine and PYGO2 role in elevated tumor invasion and metastasis, possible functional interaction between these factors may promote a process which induces invasion and malignant phenotype in ESCC.
Authors
- Nayyerehalsadat Hosseini (ORCID: https://orcid.org/0000-0003-0443-9371)
- Mohammad Mahdi Forghanifard (ORCID: https://orcid.org/0000-0002-7691-6897)
- Fatemeh Nourmohammadi
- Fereshteh Ahmadian Shalchi
- Mohammad Arian Ahmadian Shalchi
Institutions
- Mashhad University of Medical Sciences (IR)
- Shahid Sadoughi University of Medical Sciences and Health Services (IR)
Publication Details
- Journal
- BMC Molecular and Cell Biology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1186/s12860-025-00540-0
- Citations
- 1
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.80