Aberrant Glycosylation of <scp>IgG</scp> in Children With Active Lupus Nephritis Alters Podocyte Metabolism and Causes Podocyte Injury
Aberrant IgG glycosylation develops in children with LN and adversely alters podocyte metabolism, rendering these cells vulnerable to injury. Successful treatment reverses IgG glycosylation to patterns comparable to those in patients with nonrenal SLE. These data lay a strong foundation for larger translational studies evaluating the potential of IgG glycosylation as a predictive and pharmacodynamic biomarker for LN. This work also supports a need for the development of approaches to control the aberrant glycosylation of self-targeting IgG in patients with LN as a mechanism to minimize podocytopathy.
Authors
- Richard D. Cummings (ORCID: https://orcid.org/0000-0002-8918-5034)
- George C. Tsokos (ORCID: https://orcid.org/0000-0001-9589-2360)
- Rhea Bhargava
- Prasad V. G. Katakam (ORCID: https://orcid.org/0000-0002-4708-9140)
- Rohit Upadhyay (ORCID: https://orcid.org/0000-0003-1859-7784)
- Scott E. Wenderfer (ORCID: https://orcid.org/0000-0002-8991-8277)
- Maria Tsokos (ORCID: https://orcid.org/0000-0001-8072-1358)
- Hua He (ORCID: https://orcid.org/0000-0001-8989-0297)
- Tianshou Zhao (ORCID: https://orcid.org/0000-0003-4825-2381)
- Jing Chen (ORCID: https://orcid.org/0000-0003-1852-1843)
Institutions
- Tulane University (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- University of British Columbia (CA)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1002/art.43200
- Citations
- 6
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 8.58
Funders
- National Institute of Allergy and Infectious Diseases