Increased protein expression of interleukin-10 and its signalling molecules in colon cancer progression: potential prognostic and therapeutic targets
IL-10 and its signalling molecules increased in CRC progression, particularly in RSCs, suggesting their potential oncogenic roles and prognostic significance. Furthermore, targeting IL-10 signalling pathways could offer a promising avenue for CRC treatment. However, further studies are required to explore the IL-10 system in relation to tumour consensus molecular subtypes to better elucidate its biological functions and prognostic values in CRC.
Authors
- Mohamed Elzubier
- Abdulrahman Mujalli (ORCID: https://orcid.org/0000-0002-8630-3963)
- Bassem Refaat (ORCID: https://orcid.org/0000-0003-4267-1016)
- Shakir Idris (ORCID: https://orcid.org/0000-0002-2062-7893)
- Afnan Salaka
- Faisal Minshawi (ORCID: https://orcid.org/0000-0003-4677-9614)
- Mofareh Y. Alkhaldi
- Riyad A. Almaimani (ORCID: https://orcid.org/0000-0001-7944-2597)
- Wesam F. Farrash (ORCID: https://orcid.org/0000-0002-2886-9678)
- Akhmed Aslam (ORCID: https://orcid.org/0000-0002-0416-936X)
- Hassan A. Asiri
- Ahmad A. Obaid (ORCID: https://orcid.org/0000-0003-2678-4424)
- Ahmed Almalki (ORCID: https://orcid.org/0000-0002-4155-6676)
- Alì A
- Mohammad A Baqassi
- Othman M Hakmi
Institutions
- Umm al-Qura University (SA)
- King Fahd Hospital of the University (SA)
- King Fahad Specialist Hospital (SA)
- Prince Mohammed bin Abdulaziz Hospital (SA)
- Health Affairs (US)
- King Abdulaziz Hospital (SA)
- King Abdullah Medical City (SA)
- Asir Central Hospital (SA)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1007/s12672-025-02452-z
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Umm Al-Qura University