Role of oxysterol 4β-hydroxycholesterol and liver X receptor alleles in pre-eclampsia
Our results demonstrate that plasma 4βHC and genetic LXR variants do not play a major role in PE and BP regulation during pregnancy. However, key LXR target genes involved in lipid metabolism were expressed differently in normal and PE pregnancies. Further research is needed to understand the complexities of oxysterols, LXRs, and their potential contributions to placental function and pregnancy outcomes.
Authors
- Eero Kajantie (ORCID: https://orcid.org/0000-0001-7081-8391)
- Tiina Jääskeläinen (ORCID: https://orcid.org/0000-0002-1202-0936)
- Satu Wedenoja (ORCID: https://orcid.org/0000-0003-0212-4851)
- Heta Merikallio (ORCID: https://orcid.org/0000-0002-0967-3987)
- Hannele Laivuori
- Liisa Kaartinen
- Seppo Heinonen (ORCID: https://orcid.org/0000-0001-5949-0874)
- Valtteri Rinne
- Shintaro Katayama (ORCID: https://orcid.org/0000-0001-7581-5157)
- Eeva Sliz (ORCID: https://orcid.org/0000-0002-2316-058X)
- Janne Hukkanen (ORCID: https://orcid.org/0000-0003-4981-0525)
- Juha Kere (ORCID: https://orcid.org/0000-0003-1974-0271)
- Eeva Sliz
- Gamze Yazgeldi Gunaydin
Institutions
- University of Helsinki (FI)
- Tampere University (FI)
- Norwegian University of Science and Technology (NO)
- Oulu University Hospital (FI)
- Helsinki University Hospital (FI)
- Karolinska Institutet (SE)
- Finnish Institute for Health and Welfare (FI)
- Pirkanmaa Hospital District (FI)
- Tampere University Hospital (FI)
- Tampere University (FI)
- Institute for Molecular Medicine Finland (FI)
- Food & Nutrition (NL)
- Folkhälsans Forskningscentrum (FI)
- University of Oulu (FI)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1080/07853890.2025.2495763
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pfizer
- AbbVie
- Boehringer Ingelheim
- Academy of Finland
- Jane ja Aatos Erkon Säätiö
- Juho Vainion Säätiö
- Päivikki ja Sakari Sohlbergin Säätiö
- Signe ja Ane Gyllenbergin Säätiö
- Emil Aaltosen Säätiö
- Sydäntutkimussäätiö
- Business Finland
- Genentech