BDNF coexpresses with MTOR and is associated with muscle fiber size, lean mass and power-related traits
Our study demonstrates a positive correlation between BDNF and MTOR gene expression in human skeletal muscle, with genetically predicted higher BDNF expression associated with greater muscle fiber size, lean mass, enhanced power performance, and power athlete status.
Authors
- Andrey K. Larin (ORCID: https://orcid.org/0000-0002-9429-792X)
- Erdal Zorba (ORCID: https://orcid.org/0000-0001-7861-8204)
- Hasan Hüseyin Kazan (ORCID: https://orcid.org/0000-0001-7936-8606)
- Ekaterina A. Semenova (ORCID: https://orcid.org/0000-0003-1248-2855)
- Nikolay A. Kulemin (ORCID: https://orcid.org/0000-0002-8588-3206)
- Işık Bayraktar (ORCID: https://orcid.org/0000-0003-1001-5348)
- George B. John (ORCID: https://orcid.org/0000-0002-1345-7216)
- Edward V. Generozov (ORCID: https://orcid.org/0000-0002-6314-4883)
- Celal Bulğay (ORCID: https://orcid.org/0000-0003-4026-9883)
- Rinat Sultanov (ORCID: https://orcid.org/0000-0003-3918-708X)
- Ildus I. Ahmetov (ORCID: https://orcid.org/0000-0002-6335-4020)
- R. Yu. Yusupov (ORCID: https://orcid.org/0000-0001-5472-4555)
- Merve Uca (ORCID: https://orcid.org/0000-0003-3325-8828)
- Mehmet Ali Ergün (ORCID: https://orcid.org/0000-0001-9696-0433)
Institutions
- Bingöl University (TR)
- Kazan State Medical University (RU)
- Kazan State Technical University named after A. N. Tupolev (RU)
- Gülhane Askerî Tıp Akademisi (TR)
- Alanya University (TR)
- Federal Scientific Center of Physical Culture and Sports (RU)
- Sağlık Bilimleri Üniversitesi (TR)
- Dubai Medical College (AE)
- Department of Public Health (MM)
- Volga Region State Academy of Physical Culture, Sports and Tourism (RU)
- Istanbul Medeniyet University (TR)
- Liverpool John Moores University (GB)
- Federal Medical-Biological Agency (RU)
- University of Health Sciences Antigua (AG)
- Gazi University (TR)
Publication Details
- Journal
- European Journal of Applied Physiology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1007/s00421-025-05804-3
- Citations
- 3
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Russian Science Foundation