Wavefront Aberrometry in Pseudophakic Patients Before and After Vitrectomy for Bothersome Floaters

<b>Introduction:</b> To investigate whether the outcome of patients with persistent bothersome floaters who are managed with vitrectomy can be correlated with improvements in higher-order aberrations with wavefront aberrometry. <b>Methods:</b> Pseudophakic patients who had 27-gauge vitrectomy for persistent floaters and whose clinical assessment included preoperative and postoperative wavefront aberrometry were included. The primary outcome was the change in the higher-order aberration percentage measured by wavefront aberrometry. <b>Results:</b> The study included 76 eyes of 66 patients with a mean age (±SD) of 67.8 ± 7.5 years. The Snellen visual acuity improved from 20/32 preoperatively to 20/25 postoperatively (<i>P</i> = .004). Wavefront aberrometry showed a highly significant reduction in the higher-order aberration percentage (<i>P</i> < .000001), with a mean preoperative percentage of 53.9 and a mean postoperative percentage of 38.3. Subgroup analysis found a significant reduction in patients with no previous posterior capsulotomy (<i>P</i> = .001), previous neodymium:YAG capsulotomy (<i>P</i> < .000001), a monofocal intraocular lens (IOL) (<i>P</i> < .000001), and a multifocal IOL (<i>P</i> = .006). There was no significant difference in the mean preoperative and postoperative pupil size, sphere, cylinder, or spherical equivalent. <b>Conclusions:</b> Wavefront aberrometry demonstrates an objective, significant reduction in higher-order aberrations immediately after vitrectomy in pseudophakic patients with bothersome floaters.