Optimization and preparation of in-situ mucoadhesive gel of azithromycin hydroxypropyl-β-cyclodextrin inclusion complex against upper respiratory tract infections
The developed mucoadhesive in situ gels demonstrated promising in vivo performance, primarily due to their effective antimicrobial activity. In vivo, local retention studies confirmed that the formulations adhered to the throat mucosa and remained in place for up to 24 h after application. The findings presented here suggested that this localized delivery system could serve as a useful strategy for improving the therapeutic effects of ATM against URTIs.
Authors
- Goutam Rath (ORCID: https://orcid.org/0000-0001-6921-7513)
- Rakesh K. Sahoo (ORCID: https://orcid.org/0000-0002-8385-935X)
- Jitu Halder (ORCID: https://orcid.org/0000-0001-5459-2775)
- Goutam Ghosh (ORCID: https://orcid.org/0000-0002-8887-3310)
- Ivy Saha
- Salim Manoharadas (ORCID: https://orcid.org/0000-0002-1875-5976)
- Kumar Vineet (ORCID: https://orcid.org/0000-0002-8077-1299)
- Debahuti Mishra (ORCID: https://orcid.org/0000-0002-9847-1411)
- Deepak Pradhan (ORCID: https://orcid.org/0009-0003-5464-0281)
- Biswakanth Kar (ORCID: https://orcid.org/0000-0002-4530-1005)
- Muralidhar Tata
- Ritu Mahanty (ORCID: https://orcid.org/0009-0009-3122-9127)
- Ajit Mishra (ORCID: https://orcid.org/0000-0003-4839-1699)
Institutions
- Siksha O Anusandhan University (IN)
- King Saud University (SA)
- UNSW Sydney (AU)
Publication Details
- Journal
- BMC Pharmacology and Toxicology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1186/s40360-025-00936-w
- Citations
- 2
- Primary Topic
- Advanced Drug Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 1.58
Funders
- Department of Biotechnology, Ministry of Science and Technology, India
- King Saud University