Review questions sustained efficacy of esketamine in treatment‐resistant depression

Results of a systematic review and meta‐analysis suggest that esketamine has only modest efficacy in the treatment of adults with treatment‐resistant depression, with initial improvement diminishing after the first few days. The results also suggest no effect of esketamine on suicidality.

Publication Details

Journal
The Brown University Psychopharmacology Update
Published
2025-04-29
DOI
https://doi.org/10.1002/pu.31310
Primary Topic
Treatment of Major Depression
Type
article
Field-Weighted Citation Impact
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article

Review questions sustained efficacy of esketamine in treatment‐resistant depression

The Brown University Psychopharmacology Update
Treatment of Major Depression
article

Review questions sustained efficacy of esketamine in treatment‐resistant depression

article en

Abstract

Results of a systematic review and meta‐analysis suggest that esketamine has only modest efficacy in the treatment of adults with treatment‐resistant depression, with initial improvement diminishing after the first few days. The results also suggest no effect of esketamine on suicidality.

The Brown University Psychopharmacology UpdateVol. 36(6)
Openalex Percentile: Top 89%
Treatment of Major Depression
DOIOpen Access PDFOpenAlex
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Review questions sustained efficacy of esketamine in treatment‐resistant depression · The Brown University Psychopharmacology Update (2025) | TGRS Research Map | TGRS