COVID-19 mRNA-1273 vaccination induced mast cell activation with strongly elevated Th2 cytokines in a systemic mastocytosis patient
A mRNA-1273 first booster vaccination likely caused a delayed severe MCA attack with highly elevated Th<sub>2</sub>-biased cytokines with metabolic and lipidomic derangements. Administration of an IL-6 receptor blocker during both MCA attacks might have shortened the duration of clinical symptoms.
Authors
- Matthias Weiss-Tessbach (ORCID: https://orcid.org/0000-0003-0131-9091)
- Jakob Mühlbacher (ORCID: https://orcid.org/0000-0002-8592-8259)
- Thomas Boehm (ORCID: https://orcid.org/0000-0002-8294-0797)
- Teresa Haider (ORCID: https://orcid.org/0000-0002-0497-4369)
- Lorenz Schubert (ORCID: https://orcid.org/0000-0001-9181-8614)
- Jelena Brankovic
- Markus Wahrmann (ORCID: https://orcid.org/0000-0002-1301-8694)
- Bernd Jilma (ORCID: https://orcid.org/0000-0001-5652-7977)
- Aoife Gowran (ORCID: https://orcid.org/0000-0003-1098-3357)
Institutions
- Medical University of Vienna (AT)
Publication Details
- Journal
- Inflammation Research
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1007/s00011-025-02032-5
- Citations
- 4
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- Medizinische Universität Wien