Long‐term dopamine receptor blockade not linked to psychotic relapse

A cohort study has found that long‐term use of dopamine D2 receptor antagonists was not associated with increased risk of breakthrough psychosis in patients with first‐­episode schizophrenia. Risk of relapse within the cohort decreased over time, the investigators reported. Study results were published online Feb. 19, 2025, in the American Journal of Psychiatry .

Publication Details

Journal
The Brown University Psychopharmacology Update
Published
2025-04-29
DOI
https://doi.org/10.1002/pu.31308
Primary Topic
Schizophrenia research and treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Long‐term dopamine receptor blockade not linked to psychotic relapse

The Brown University Psychopharmacology Update
Schizophrenia research and treatment
article

Long‐term dopamine receptor blockade not linked to psychotic relapse

article en

Abstract

A cohort study has found that long‐term use of dopamine D2 receptor antagonists was not associated with increased risk of breakthrough psychosis in patients with first‐­episode schizophrenia. Risk of relapse within the cohort decreased over time, the investigators reported. Study results were published online Feb. 19, 2025, in the American Journal of Psychiatry .

The Brown University Psychopharmacology UpdateVol. 36(6)
Openalex Percentile: Top 89%
Schizophrenia research and treatment
DOISourceOpenAlex
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Long‐term dopamine receptor blockade not linked to psychotic relapse · The Brown University Psychopharmacology Update (2025) | TGRS Research Map | TGRS