Repetitive prefrontal tDCS activates VTA dopaminergic neurons, resulting in attenuation of Alzheimer’s Disease-like deficits in Tg2576 mice
These findings highlight the multifaceted therapeutic potential of prefrontal tDCS in targeting key AD pathophysiological hallmarks, including dopaminergic dysfunction, synaptic impairments, neuroinflammation and plaque deposition. As a non-invasive neuromodulatory approach, prefrontal tDCS emerges as a promising early intervention strategy to complement existing AD treatments, with the potential to improve patient outcomes and quality of life.
Authors
- Marcello D’Amelio (ORCID: https://orcid.org/0000-0001-6526-1832)
- Annalisa Nobili (ORCID: https://orcid.org/0000-0001-8369-1561)
- Paraskevi Krashia (ORCID: https://orcid.org/0000-0002-8476-9233)
- Lucy Babicola (ORCID: https://orcid.org/0000-0002-5373-5225)
- Stefano Puglisi‐Allegra (ORCID: https://orcid.org/0000-0002-9433-2000)
- Emanuele Claudio Latagliata (ORCID: https://orcid.org/0000-0001-8402-2757)
- Matteo Di Segni (ORCID: https://orcid.org/0000-0002-1453-579X)
- Emma Cauzzi (ORCID: https://orcid.org/0000-0003-0236-5276)
- Livia La Barbera (ORCID: https://orcid.org/0000-0003-4556-4451)
- Roberto Coccurello (ORCID: https://orcid.org/0000-0001-7059-7015)
- Gilda Loffredo
- Maria Luisa De Paolis
Institutions
- Università Campus Bio-Medico (IT)
- Istituto Neurologico Mediterraneo (IT)
- Institute for Complex Systems (IT)
- Fondazione Santa Lucia (IT)
- IRCCS Eugenio Medea (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1186/s13195-025-01736-4
- Citations
- 9
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 7.58
Funders
- Alzheimer's Association
- Ministero della Salute
- Università Campus Bio-Medico di Roma
- Fondazione Roma
- Associazione Italiana Ricerca Alzheimer