The autocrine motility factor receptor delays the pathological progression of Alzheimer’s disease via regulating the ubiquitination-mediated degradation of APP
Taken together, our results demonstrated that AMFR reduced Aβ production and alleviated cognitive impairment by promoting the ubiquitination-mediated degradation of APP. This study indicated that AMFR could have the potential to be a therapeutic target of early-stage AD.
Authors
- Yuting Cui (ORCID: https://orcid.org/0000-0001-7594-1911)
- Song Qiao (ORCID: https://orcid.org/0000-0002-8590-0926)
- Peichang Wang (ORCID: https://orcid.org/0000-0002-7970-9797)
- Xiaomin Zhang (ORCID: https://orcid.org/0000-0003-4898-4152)
- Xiaoling Wang (ORCID: https://orcid.org/0000-0001-9767-6792)
- Yaqi Wang (ORCID: https://orcid.org/0000-0002-8003-6251)
- Jingjing Zhang (ORCID: https://orcid.org/0000-0002-9155-8979)
- Qian Zhang (ORCID: https://orcid.org/0000-0003-4928-3366)
- Wenchao Wang (ORCID: https://orcid.org/0000-0003-0757-4878)
- Congcong Liu (ORCID: https://orcid.org/0000-0002-1989-6711)
- Min Cao (ORCID: https://orcid.org/0000-0002-0909-8871)
- Yuli Hou (ORCID: https://orcid.org/0000-0002-8370-0605)
- Jing Liu (ORCID: https://orcid.org/0000-0002-3255-3019)
Institutions
- Capital Medical University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Beijing Hospital (CN)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1186/s13195-025-01741-7
- Citations
- 2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- National Natural Science Foundation of China
- Capital Medical University