Genetic Variation in the blaZ Gene Leading to the BORSA Phenotype in Staphylococcus aureus
Our findings demonstrate that the new F variant of BlaZ is sufficient to render <i>S. aureus</i> a BORSA strain, which is superior in the degradation of common anti-staphylococcal β-lactam antibiotics, such as benzylpenicillin, cloxacillin, and oxacillin. It is sensitive to β-lactamase inhibitors and rapidly degrades nitrocefin. We provide a genetic explanation for the borderline oxacillin-resistant <i>S. aureus</i> (BORSA) phenotype.
Authors
- Godefroid Charbon (ORCID: https://orcid.org/0000-0003-4792-1889)
- Michael Kemp (ORCID: https://orcid.org/0000-0001-5989-0421)
- Henrik Westh (ORCID: https://orcid.org/0000-0001-5681-647X)
- Karen Leth Nielsen (ORCID: https://orcid.org/0000-0002-7912-1985)
- Alex Yuri Simões Sato (ORCID: https://orcid.org/0000-0002-4085-2000)
- Frederik Boëtius Hertz (ORCID: https://orcid.org/0000-0003-0888-4616)
- Helle Krogh Johansen (ORCID: https://orcid.org/0000-0003-0268-3717)
- Svend Ellermann‐Eriksen (ORCID: https://orcid.org/0000-0001-9324-911X)
- Anders Løbner‐Olesen (ORCID: https://orcid.org/0000-0002-0344-6417)
- Mia Aarris (ORCID: https://orcid.org/0009-0001-7074-3219)
- Niels Frimodt‐Møller (ORCID: https://orcid.org/0000-0003-1966-8302)
Institutions
- University of Copenhagen (DK)
- Odense University Hospital (DK)
- Hvidovre Hospital (DK)
- Aarhus University Hospital (DK)
- Rigshospitalet (DK)
Publication Details
- Journal
- Antibiotics
- Published
- 2025-04-29
- DOI
- https://doi.org/10.3390/antibiotics14050449
- Citations
- 1
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Lundbeckfonden
- Novo Nordisk Fonden