“The role of mitogen-activated protein kinase signaling pathway in bone formation during mid-palatal suture expansion”
Mechanical activation of MEK-ERK1/2-ELK1 pathway is essential for effective maxillary expansion. Thus, inhibiting this pathway significantly impairs bone remodeling, underscoring its potential as a therapeutic target to enhance bone formation in orthodontic treatments.
Authors
- Shujuan Zou (ORCID: https://orcid.org/0000-0001-5597-5049)
- Jianwei Chen (ORCID: https://orcid.org/0000-0002-1918-1847)
- Xiaoyue Xiao (ORCID: https://orcid.org/0000-0003-1036-3545)
- Zhiai Hu (ORCID: https://orcid.org/0000-0001-7394-0341)
Institutions
- Sichuan University (CN)
- Stomatological Hospital of Chongqing Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Connective Tissue Research
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1080/03008207.2025.2498509
- Primary Topic
- Craniofacial Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing