Temporal network analysis of gut microbiota unveils aging trajectories associated with colon cancer
This study underscores the critical role of the gut microbiome in colorectal cancer (CRC) pathogenesis, particularly in the context of aging. By identifying age-specific microbial biomarkers and functional pathways associated with CRC, our findings provide novel insights into how microbiome composition and metabolic activities influence disease progression. These discoveries pave the way for developing personalized microbiome-based diagnostic tools and therapeutic strategies, potentially improving CRC prevention and treatment outcomes across different age groups. Understanding these microbial dynamics could also inform interventions targeting gut microbiota to mitigate CRC risk and progression.
Authors
- Zhipeng Zhang (ORCID: https://orcid.org/0000-0002-5346-3055)
- Jianhui Tian (ORCID: https://orcid.org/0000-0003-1577-9179)
- Meng Xu (ORCID: https://orcid.org/0000-0002-1223-7668)
- Qian Ba (ORCID: https://orcid.org/0000-0002-7253-7566)
- Ning‐Ning Liu (ORCID: https://orcid.org/0000-0002-1468-6897)
- Chenyue Yuan (ORCID: https://orcid.org/0000-0002-4124-8788)
- Ziqi Chen (ORCID: https://orcid.org/0009-0005-5995-6546)
- Long Zhang (ORCID: https://orcid.org/0000-0001-8139-0474)
- Ziliang Wang (ORCID: https://orcid.org/0000-0002-2702-5887)
- Wei Huang (ORCID: https://orcid.org/0009-0007-8139-3596)
- Ying Zhu (ORCID: https://orcid.org/0009-0008-8211-105X)
- Bei Ning Nie
- Mengfei Wang (ORCID: https://orcid.org/0009-0009-1924-4690)
- Xinyi Wang (ORCID: https://orcid.org/0009-0006-0731-6069)
Institutions
- Shanghai Jiao Tong University (CN)
- University of California San Diego (US)
- Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- mSystems
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1128/msystems.01188-24
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Science and Technology Innovation Plan Of Shanghai Science and Technology Commission