DENV2 and ZIKV modulate the feeding behavior of <i>Aedes aegypti</i> by altering the tyrosine-dopamine pathway
This study sheds light on how DENV2 and ZIKV affect the feeding behavior of mosquitoes. We discovered the molecular mechanisms that lead to increased movement and blood feeding in mosquitoes by altering neurotransmitter levels and disrupting their internal biological clocks. These findings reveal how these viruses enhance their own transmission by making mosquitoes more active. This research could help in developing strategies to target these processes, ultimately aiding efforts to control the spread of dengue and Zika viruses and reducing the risk of outbreaks.
Authors
- Yan Liang (ORCID: https://orcid.org/0000-0002-1847-1703)
- Jichen Niu
- Yibin Zhu (ORCID: https://orcid.org/0000-0002-8088-3960)
- Yicheng Wang (ORCID: https://orcid.org/0000-0002-6364-137X)
- Gong Cheng (ORCID: https://orcid.org/0000-0001-7447-5488)
- Dong‐Min Gao (ORCID: https://orcid.org/0000-0002-9530-8862)
- Zhaoyang Wang (ORCID: https://orcid.org/0000-0002-3124-7060)
- Gang Wang (ORCID: https://orcid.org/0009-0009-2453-1854)
- R. Jiang (ORCID: https://orcid.org/0009-0002-3001-764X)
Institutions
- Peking University (CN)
- King Center (US)
- Shenzhen Bay Laboratory (CN)
- Shenzhen Center for Disease Control and Prevention (CN)
- Center for Life Sciences (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- mBio
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1128/mbio.03968-24
- Citations
- 3
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China