The inhibitory receptor LAG3 affects NK cell IFN-γ production through glycolysis and the PSAT1/STAT1/IFNG pathway
We demonstrate that lymphocyte activation gene 3 (LAG3) expression is upregulated on natural killer (NK) cells during HIV infection. LAG3 inhibits glycolysis in NK cells and also upregulates PSAT1 expression to suppress activation of the STAT1/IFNG pathway, thus restricting interferon-gamma production by NK cells. These results provide new clues to study the effects of LAG3 on the metabolism and functional exhaustion of NK cells and offer a potential target for the treatment of HIV.
Authors
- Xiaowen Yu (ORCID: https://orcid.org/0000-0001-6514-2307)
- Hong Shang (ORCID: https://orcid.org/0000-0001-5333-8943)
- Hongchi Ge (ORCID: https://orcid.org/0009-0005-4306-6071)
- Bin Lang
- Nan Guo (ORCID: https://orcid.org/0009-0005-0242-8769)
- Haibo Ding (ORCID: https://orcid.org/0000-0002-9445-5473)
- Yajing Fu
- Qinghai Hu (ORCID: https://orcid.org/0000-0002-1084-8748)
- Wenqing Geng (ORCID: https://orcid.org/0000-0002-7008-9974)
- Xiaoxu Han (ORCID: https://orcid.org/0000-0003-1427-8428)
- Zining Zhang (ORCID: https://orcid.org/0000-0002-3003-3546)
- Xiaowan Yin
- Yufei Liu (ORCID: https://orcid.org/0009-0007-7759-2875)
- Yongjun Jiang (ORCID: https://orcid.org/0000-0002-8606-3971)
Institutions
- First Hospital of China Medical University (CN)
Publication Details
- Journal
- mBio
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1128/mbio.00230-25
- Citations
- 7
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 5.58