Photo-Thiocyanoamination of π- and σ-Bonds: Reagent Development and Synthetic Applications

1,2-Thiocyanoamines make up a class of important structural motifs that are found in a number of bioactive molecules and precursors to many more. Despite their synthetic significance, expedient access to this difunctionalization is rare. Herein, the development of a thiocyanoimination reagent is disclosed, taking advantage of photomediated energy transfer phenomena for the facile thiocyanoimination of alkenes. The strategy was found to be viable for σ-bonds as well, providing a generalized strategy for accessing small molecules infused with amine and -SCN.