Causal association between immune cell phenotypes and colorectal cancer: a two-sample bidirectional Mendelian randomization analysis

Our study provides evidence for a causal relationship between immune cell phenotypes and CRC. These findings suggest that immune cell characteristics may serve as potential biomarkers for CRC and could represent novel therapeutic targets. However, further experimental research is needed to explore the underlying mechanisms in greater detail and to validate the clinical applicability of these findings.

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Publication Details

Journal
Discover Oncology
Published
2025-04-29
DOI
https://doi.org/10.1007/s12672-025-02443-0
Citations
1
Primary Topic
Genetic Associations and Epidemiology
Type
article
Field-Weighted Citation Impact
1.82
Controls
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article

Causal association between immune cell phenotypes and colorectal cancer: a two-sample bidirectional Mendelian randomization analysis

Huiying Fang, Wei Jiang, You Zheng
1 citations
Discover Oncology
Genetic Associations and Epidemiology
1.82
article

Causal association between immune cell phenotypes and colorectal cancer: a two-sample bidirectional Mendelian randomization analysis

Huiying Fang, Wei Jiang, You Zheng
article en
1 citations

Abstract

Our study provides evidence for a causal relationship between immune cell phenotypes and CRC. These findings suggest that immune cell characteristics may serve as potential biomarkers for CRC and could represent novel therapeutic targets. However, further experimental research is needed to explore the underlying mechanisms in greater detail and to validate the clinical applicability of these findings.

Discover OncologyVol. 16(1)
Dalian Medical University (CN), Second Affiliated Hospital of Chongqing Medical University (CN), Chongqing Medical University (CN)
Good health and well-being
Openalex Percentile: Top 16%
Genetic Associations and Epidemiology
1.82
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