Causal association between immune cell phenotypes and colorectal cancer: a two-sample bidirectional Mendelian randomization analysis
Our study provides evidence for a causal relationship between immune cell phenotypes and CRC. These findings suggest that immune cell characteristics may serve as potential biomarkers for CRC and could represent novel therapeutic targets. However, further experimental research is needed to explore the underlying mechanisms in greater detail and to validate the clinical applicability of these findings.
Authors
- Huiying Fang (ORCID: https://orcid.org/0009-0001-5122-2485)
- Wei Jiang (ORCID: https://orcid.org/0000-0001-5229-3587)
- You Zheng (ORCID: https://orcid.org/0000-0002-3259-2253)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1007/s12672-025-02443-0
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.82