Liver steatosis is positively associated with plasminogen activator inhibitor-1 in apparently healthy individuals with overweight and obesity: A FibroScan-Based Cross-Sectional study
Circulating PAI-1 levels are correlated with liver steatosis and, to a lesser extent, fibrosis in apparently healthy patients with a BMI ≥ 25 kg/m<sup>2</sup>. This is the first study to show these results in patients naïve to medications, using FibroScan assessment. The bidirectional relationship between circulating PAI-1 levels and CAP measurement highlights the relevance of our research from a diagnostic and pathophysiological-prognostic viewpoint. Longitudinal trials are needed to clarify the cause-effect association between MASLD and PAI-1 levels.
Authors
- Marianna Zappimbulso
- Davide Guido (ORCID: https://orcid.org/0000-0002-3291-3686)
- Giovanni De Pergola (ORCID: https://orcid.org/0000-0003-0020-3273)
- Pasqua Letizia Pesole (ORCID: https://orcid.org/0000-0003-4675-2075)
- Giuseppe Lisco (ORCID: https://orcid.org/0000-0001-6521-8578)
- Caterina Bonfiglio (ORCID: https://orcid.org/0000-0002-8650-348X)
- Martina Di Chito (ORCID: https://orcid.org/0009-0007-2759-8347)
- Cristiana Randazzo (ORCID: https://orcid.org/0000-0001-9081-6190)
- Sergio Coletta (ORCID: https://orcid.org/0000-0003-3359-7010)
- Domenico Barletta
- Gianluigi Giannelli (ORCID: https://orcid.org/0000-0002-5140-8060)
- Endrit Shahini (ORCID: https://orcid.org/0000-0002-4909-0436)
- Rosanna Donvito
- Nicole Cerabino
- Dolores Stabile (ORCID: https://orcid.org/0009-0000-0259-9799)
- Anna Ancona (ORCID: https://orcid.org/0009-0009-7662-1763)
Institutions
- Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo (IT)
- Gastroenterology Hospital "Saverio de Bellis" (IT)
- University of Bari Aldo Moro (IT)
- University of Palermo (IT)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1186/s12967-025-06464-9
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- Ministero della Salute