Allele Frequencies and Genotypes for the <i>Ryanodine Receptor 1</i> Variant Causing Malignant Hyperthermia and Fatal Rhabdomyolysis With Hyperthermia in Horses
Homozygotes for the MH allele were not identified, and thus might be incompatible with life, but additional testing is needed to confirm. Although the allele frequency was low, being heterozygous poses a risk of death if anesthesia, stress, concurrent illness, breeding, or other stresses occur.
Authors
- Monica Aleman
- Rebecca R. Bellone (ORCID: https://orcid.org/0000-0001-8838-7227)
- Molly E. McCue (ORCID: https://orcid.org/0000-0002-6807-0318)
Institutions
- University of Minnesota (US)
- Veterinary Medical Teaching Hospital (US)
- University of California, Davis (US)
Publication Details
- Journal
- Journal of Veterinary Internal Medicine
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1111/jvim.70081
- Citations
- 1
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- University of California, Davis