In-situ synthesis of Fe3O4@TFA-TAPA-COF as a novel sorbent coupled with UPLC-MS/MS for the determination of 22 perfluorinated compounds in water and honey

Perfluorinated compounds (PFCs) are a class of widely distributed persistent organic pollutants (POPs), attracting increased attention. Consequently, there is an urgent demand for sensitive, reliable, and high-throughput methods to detect PFCs. This study used a monomer-mediated in situ growth strategy to design and synthesize Fe 3 O 4 @TFA–TAPA–COF. Accordingly, a novel method based on Fe 3 O 4 @TFA–TAPA magnetic solid-phase extraction combined with ultra-high-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) was developed to detect 22 ultra trace PFCs from water and honey samples. Several techniques used to characterize Fe 3 O 4 @TFA–TAPA–COF showed that it had a porous structure with a large surface area (102.84 m²/g). Under optimized parameters, the ranges for the limit of detection (LOD) in water and honey were 0.42–23.44 pg/L and 3.36–187.52 pg/kg, respectively. The results indicated that Fe 3 O 4 @TFA–TAPA–COF had high selectivity , high adsorption ability, and reusability. Additionally, the proposed method exhibited good accuracy, low LOD, and good reproducibility. This method was successfully applied to determine PFCs in 54 tap water and 40 honey samples in Shijiazhuang, China, and provided methodological reference and technical support for the risk monitoring of food quality and safety. • A novel Fe 3 O 4 @TFA-TAPA-COF was synthesized via in-situ growth strategy. • Fe 3 O 4 @TFA-TAPA-COF demonstrated excellent reusability and adsorption capabilities. • This method is simple, high-throughput, high sensitivity and good selectivity. • 22 PFCs in 40 honey and 54 water samples were statistically analyzed.