Effects of anlotinib hydrochloride on the expression of immunogenic cell death-related molecules in Cal27 tongue cancer cells
AL3818 has the potential to induce ICD in the Cal27 TSCC cell line by modulating the levels of ICD-related molecules such as ATP, CRT, HSP70, and HMGB1. Moreover, the combination of AL3818 and PTX is more effective in inducing ICD in Cal27 cells compared to either agent alone. The process by which CRT is transferred from within the cell to the membrane during the induction of ICD in the Cal27 cell line by AL3818 may be related to the phosphorylation and activation of the PERK/elF2a signaling pathway.
Authors
- Jitao Zhu
- Lijuan Guo (ORCID: https://orcid.org/0000-0003-4978-3731)
- Pengcheng Huang (ORCID: https://orcid.org/0000-0002-1371-6687)
- Zong Yao Zhang
- Sen Yang (ORCID: https://orcid.org/0000-0002-3958-5574)
- Guan Li (ORCID: https://orcid.org/0000-0003-4196-0051)
Institutions
- Zunyi Medical University (CN)
- Southwest Medical University (CN)
- Suizhou Central Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1007/s12672-025-02464-9
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Science and Technology of Sichuan Province
- Sichuan Provincial Administration of Traditional Chinese Medicine
- Chinese Stomatological Association
- Health Commission of Sichuan Province