A multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder
We integrated genome-wide measures of mRNA and miRNA expression and proteomics profiling from PTSD, MDD, and control (CON) brains to identify convergent and divergent molecular processes across genomic modalities. We substantially expand the number of differentially expressed genes and proteins in PTSD and identify downregulation of GABAergic processes in the PTSD proteome. This provides a novel framework for future studies integrating proteomic profiling with transcriptomics and non-coding RNAs in the human brain studies.
Authors
- TuKiet T. Lam (ORCID: https://orcid.org/0000-0002-4850-3462)
- Matthew J. Friedman (ORCID: https://orcid.org/0000-0002-0497-6890)
- John Lee Soto-Vargas (ORCID: https://orcid.org/0000-0001-7921-8958)
- Yujing Liu (ORCID: https://orcid.org/0000-0002-0250-9631)
- Angus C. Nairn (ORCID: https://orcid.org/0000-0002-7075-0195)
- Chi Zhang (ORCID: https://orcid.org/0000-0001-6009-5273)
- T. P. Nhung Nguyen (ORCID: https://orcid.org/0000-0001-9506-7838)
- Rashaun S. Wilson
- Kenneth R. Williams (ORCID: https://orcid.org/0000-0001-7792-9588)
- Keith A. Young (ORCID: https://orcid.org/0000-0001-6060-3573)
- David A. Lewis (ORCID: https://orcid.org/0000-0002-3225-6778)
- Ronald S. Duman (ORCID: https://orcid.org/0000-0001-8690-8439)
- Weiwei Wang (ORCID: https://orcid.org/0000-0003-3995-2095)
- Jiawei Wang (ORCID: https://orcid.org/0000-0003-2627-4897)
- Hongyu Li (ORCID: https://orcid.org/0000-0001-6525-9310)
- Lin Chen (ORCID: https://orcid.org/0000-0001-7905-2505)
Institutions
- Dartmouth College (US)
- University of Pittsburgh (US)
- W. M. Keck Foundation (US)
- Yale University (US)
- Central Texas Veterans Health Care System (US)
- National Center for Post Traumatic Stress Disorder (US)
- Bryan College (US)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1186/s13073-025-01473-1
- Citations
- 3
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.73
Funders
- U.S. Department of Veterans Affairs
- Brain and Behavior Research Foundation
- American Foundation for Suicide Prevention
- Yale University
- University of Pittsburgh
- National Institutes of Health
- National Center for PTSD, U.S. Department of Veterans Affairs
- National Institute on Drug Abuse