Kaempferol ameliorated central nervous injury induced by alcohol uptake through improving intestinal barrier function

KAE treatment enhanced intestinal barrier function to alleviate neuronal damage caused by microglial activation mediated by gut-derived LPS under alcohol expose. This effect of KAE was involved in the enhance of intestinal occludin expression by inhibiting the expression of miRNA-122a. This suggested that KAE had the potential to prevent alcohol-induced neurological damage.

Authors

Jingjing Chen (ORCID: https://orcid.org/0000-0002-6483-0199)
Shouhao Zhou (ORCID: https://orcid.org/0000-0002-8124-5047)
Liang Lü (ORCID: https://orcid.org/0000-0002-7778-7820)
Wenyan Zhong (ORCID: https://orcid.org/0000-0003-3364-1915)
Li Xiao (ORCID: https://orcid.org/0000-0002-3627-2513)

Institutions

China Three Gorges University (CN)

Publication Details

Journal: Neuroreport
Published: 2025-04-29
DOI: https://doi.org/10.1097/wnr.0000000000002170
Primary Topic: Alcohol Consumption and Health Effects
Type: article
Field-Weighted Citation Impact: 0.00

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article

Kaempferol ameliorated central nervous injury induced by alcohol uptake through improving intestinal barrier function

Jingjing Chen, Shouhao Zhou, Liang Lü, Wenyan Zhong et al.

Apr 29, 2025

Neuroreport

Alcohol Consumption and Health Effects

article

Kaempferol ameliorated central nervous injury induced by alcohol uptake through improving intestinal barrier function

Jingjing Chen, Shouhao Zhou, Liang Lü, Wenyan Zhong, Li Xiao

April 29, 2025article en

Abstract

KAE treatment enhanced intestinal barrier function to alleviate neuronal damage caused by microglial activation mediated by gut-derived LPS under alcohol expose. This effect of KAE was involved in the enhance of intestinal occludin expression by inhibiting the expression of miRNA-122a. This suggested that KAE had the potential to prevent alcohol-induced neurological damage.

NeuroreportVol. 36(10)

China Three Gorges University (CN)

Good health and well-being

Openalex Percentile: Top 87%

Alcohol Consumption and Health Effects

DOI Source OpenAlex

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Kaempferol ameliorated central nervous injury induced by alcohol uptake through improving intestinal barrier function — Jingjing Chen, Shouhao Zhou, et al. · Neuroreport (2025) | TGRS Research Map | TGRS