Characterization of Extrachromosomal Circular DNA in Primary and Cisplatin-Resistant High-Grade Serous Ovarian Cancer
Our findings suggest that eccDNAs, particularly ecDNA amplifications like <i>HIF1A</i>, contribute significantly to cisplatin resistance mechanisms in HGSOC. These insights highlight eccDNA as a potential target for overcoming therapeutic resistance and improving treatment outcomes in ovarian cancer.
Authors
- Zhong Sheng Sun (ORCID: https://orcid.org/0000-0002-7640-5026)
- Xiaoyun Zhu (ORCID: https://orcid.org/0000-0002-3697-4224)
- Youya Wang
- He Li (ORCID: https://orcid.org/0000-0001-7459-9202)
- Yi Li (ORCID: https://orcid.org/0000-0002-9976-518X)
- Zhiguo Zheng (ORCID: https://orcid.org/0000-0003-2142-8367)
- Ge Yan (ORCID: https://orcid.org/0009-0001-9576-7305)
- Hao Wu (ORCID: https://orcid.org/0000-0001-8010-7729)
- Qinglan Li (ORCID: https://orcid.org/0000-0002-6912-1156)
Institutions
- Chinese Academy of Sciences (CN)
- Wenzhou Medical University (CN)
- Zhejiang Cancer Hospital (CN)
- University of Chinese Academy of Sciences (CN)
- Institute of Zoology (CN)
Publication Details
- Journal
- Genes
- Published
- 2025-04-29
- DOI
- https://doi.org/10.3390/genes16050517
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China