Detection of Brain Cancer Using Genome-wide Cell-free DNA Fragmentomes
Brain cancer is one of the deadliest and most challenging cancers to detect with liquid biopsy approaches in blood, hampering efforts for earlier noninvasive diagnosis. We have developed a machine learning genome-wide cfDNA fragmentation method that provides a sensitive and accessible approach for brain cancer detection.
Authors
- Adrianna L. Bartolomucci
- Victor E. Velculescu (ORCID: https://orcid.org/0000-0003-1195-438X)
- Debraj Mukherjee (ORCID: https://orcid.org/0000-0002-5403-8237)
- Shashikant Koul (ORCID: https://orcid.org/0000-0002-9690-7349)
- Michael Lim (ORCID: https://orcid.org/0000-0003-0523-3076)
- Nicholas A. Vulpescu (ORCID: https://orcid.org/0000-0003-1310-0257)
- Ernest J. Bobeff (ORCID: https://orcid.org/0000-0003-1891-3791)
- Christopher M. Jackson (ORCID: https://orcid.org/0000-0002-5958-2004)
- Justin M. Caplan (ORCID: https://orcid.org/0000-0002-0289-3661)
- Judy Huang (ORCID: https://orcid.org/0000-0002-0675-1935)
- Elaine J. Chiao (ORCID: https://orcid.org/0000-0002-2275-9080)
- Jamie E. Medina (ORCID: https://orcid.org/0000-0002-6124-0548)
- Akshaya V. Annapragada (ORCID: https://orcid.org/0000-0002-9097-6511)
- Dimitrios Mathios (ORCID: https://orcid.org/0000-0002-0792-6880)
- Henry Brem (ORCID: https://orcid.org/0000-0001-7539-4786)
- Kavya Boyapati (ORCID: https://orcid.org/0000-0002-1731-7480)
- Robert B. Scharpf (ORCID: https://orcid.org/0000-0003-4702-2656)
- Daniel C. Bruhm (ORCID: https://orcid.org/0000-0002-8436-501X)
- Stephen Cristiano (ORCID: https://orcid.org/0000-0002-7375-2364)
- Vilmos Adleff (ORCID: https://orcid.org/0000-0002-5001-1766)
- Jillian Phallen (ORCID: https://orcid.org/0000-0002-5492-9013)
- Patrycja Stanisławska (ORCID: https://orcid.org/0000-0002-0360-2520)
- Keerti Boyapati (ORCID: https://orcid.org/0009-0009-3769-5452)
- Noushin Niknafs (ORCID: https://orcid.org/0000-0002-4852-3674)
- Gary L. Gallia (ORCID: https://orcid.org/0000-0001-6438-7329)
- Małgorzata Podstawka
- Chul‐Kee Park (ORCID: https://orcid.org/0000-0002-2350-9876)
- Leonardo Ferreira (ORCID: https://orcid.org/0000-0002-2468-2689)
- Sarah Short (ORCID: https://orcid.org/0000-0003-2319-6360)
- Jon Weingart
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Johns Hopkins University (US)
- Palo Alto University (US)
- Washington University in St. Louis (US)
- Johns Hopkins Medicine (US)
- New Generation University College (ET)
- Seoul National University Hospital (KR)
- Medical University of Lodz (PL)
- Johns Hopkins Hospital (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- Stanford University (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1158/2159-8290.cd-25-0074
- Citations
- 8
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 7.49
Funders
- Conquer Cancer Foundation
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- American Society of Clinical Oncology
- Johns Hopkins University
- Gray Foundation
- Seoul National University
- Uniwersytet Łódzki
- National Institutes of Health