The plasma proteome is linked to echocardiographic parameters and stages of diastolic dysfunction, across the ejection fraction spectrum
In patients at risk of/with HFpEF, biological processes and pathways showed weaker associations with E/e' compared to patients with HFrEF. Varying pathways identified through proteomics were associated with deterioration of LVDD across the ejection fraction spectrum. Our results are in line with the mechanistic frameworks currently thought to underlie the various types of HF.
Authors
- Bas M. van Dalen (ORCID: https://orcid.org/0000-0002-8294-7008)
- Elisa Dal Canto (ORCID: https://orcid.org/0000-0001-8999-9946)
- Sabrina Abou Kamar
- Anne-Mar van Ommen
- Gideon Valstar (ORCID: https://orcid.org/0000-0003-0684-9622)
- Victor A. Umans (ORCID: https://orcid.org/0000-0002-5587-9097)
- Rudolf A. de Boer (ORCID: https://orcid.org/0000-0002-4775-9140)
- K. Martijn Akkerhuis (ORCID: https://orcid.org/0000-0003-4833-3130)
- Frans Hendrik Rutten (ORCID: https://orcid.org/0000-0002-5052-7332)
- Folkert W. Asselbergs (ORCID: https://orcid.org/0000-0002-1692-8669)
- Leonard Hofstra (ORCID: https://orcid.org/0000-0003-4432-4720)
- Maarten J. Cramer (ORCID: https://orcid.org/0000-0002-6041-6759)
- Isabella Kardys (ORCID: https://orcid.org/0000-0002-2115-9745)
- Roxana Menken (ORCID: https://orcid.org/0000-0002-6314-9238)
- Marianne Christina Verhaar (ORCID: https://orcid.org/0000-0002-3276-6428)
- Marcel L. Geleijnse (ORCID: https://orcid.org/0000-0002-0941-3384)
- Arco J. Teske (ORCID: https://orcid.org/0000-0001-5305-1619)
- Hester M. den Ruijter (ORCID: https://orcid.org/0000-0001-9762-014X)
- Eric Boersma (ORCID: https://orcid.org/0000-0003-1159-7802)
Institutions
- University College Hospital (GB)
- Utrecht University (NL)
- Erasmus MC (NL)
- University Medical Center Utrecht (NL)
- Sint Franciscus Gasthuis (NL)
- Noordwest Ziekenhuisgroep (NL)
- The Centers (US)
- Erasmus MC Cancer Institute (NL)
- Amsterdam University Medical Centers (NL)
- University College London (GB)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- International Journal of Cardiology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1016/j.ijcard.2025.133329
- Citations
- 2
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- European Federation of Pharmaceutical Industries and Associations
- Dutch Cardiovascular Alliance
- Jaap Schouten Foundation
- Netherlands Heart Institute