Pathological contributors to organ damage and mortality in systemic sclerosis: a nationwide matched case-control study
The high frequency of unexplained myocardial fibrosis in SSc provides insights into the mechanism of excess mortality and sudden cardiac death observed in SSc. This matched autopsy study demonstrates the mechanisms and complexity of organ damage in SSc, with 30-45 % of organs displaying multiple concurrent pathologies.
Authors
- Penelope A McKelvie (ORCID: https://orcid.org/0000-0002-6089-9105)
- Laura Ross (ORCID: https://orcid.org/0000-0003-4636-729X)
- Mandana Nikpour (ORCID: https://orcid.org/0000-0002-6585-5611)
- André La Gerche (ORCID: https://orcid.org/0000-0002-3906-3784)
- Jessica L. Fairley (ORCID: https://orcid.org/0000-0003-4140-2711)
- Wendy Stevens
- Elizabeth Davida Paratz (ORCID: https://orcid.org/0000-0002-2122-9889)
- Dylan Hansen (ORCID: https://orcid.org/0000-0001-5777-7476)
Institutions
- Royal Prince Alfred Hospital (AU)
- St Vincent's Hospital Melbourne (AU)
- Melbourne Health (AU)
- St Vincents Institute of Medical Research (AU)
Publication Details
- Journal
- Seminars in Arthritis and Rheumatism
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1016/j.semarthrit.2025.152739
- Citations
- 8
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 11.77