Sex Differences in Lung B Cell Responses in a Murine Model of Asthma
In a murine asthma model, sex differences in whole-lung B lymphocytes are primarily driven by higher numbers of naïve B cells and plasmablasts in females versus males. Our results suggest that sex chromosomes and sex hormones may influence B-cell subsets during allergic lung inflammation.
Authors
- Li Y. Drake (ORCID: https://orcid.org/0000-0002-4660-7647)
- Sergio E. Chiarella (ORCID: https://orcid.org/0000-0002-0445-4929)
- Kimberly E. Stelzig (ORCID: https://orcid.org/0000-0001-5822-0397)
- Sergejs Berdnikovs (ORCID: https://orcid.org/0000-0001-5186-3293)
- Ana M. Hernandez-Botero
Institutions
- Northwestern University (US)
- Mayo Clinic (US)
Publication Details
- Journal
- International Archives of Allergy and Immunology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1159/000546024
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00